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Sensitivity of mRNA Translation

Using the dynamic mean-field approximation of the totally asymmetric simple exclusion process (TASEP), we investigate the effect of small changes in the initiation, elongation, and termination rates along the mRNA strand on the steady-state protein translation rate. We show that the sensitivity of m...

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Detalles Bibliográficos
Publicado en:Sci Rep
Main Authors: Poker, Gilad, Margaliot, Michael, Tuller, Tamir
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2015
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4523843/
https://ncbi.nlm.nih.gov/pubmed/26238363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep12795
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