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Sensitivity of mRNA Translation

Using the dynamic mean-field approximation of the totally asymmetric simple exclusion process (TASEP), we investigate the effect of small changes in the initiation, elongation, and termination rates along the mRNA strand on the steady-state protein translation rate. We show that the sensitivity of m...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Poker, Gilad, Margaliot, Michael, Tuller, Tamir
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4523843/
https://ncbi.nlm.nih.gov/pubmed/26238363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep12795
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