Cross-linking of T-cell receptors on double-positive thymocytes induces a cytokine-mediated stromal activation process linked to cell death.

To investigate molecular events associated with the intrathymic process of negative selection, we established an in vivo system using an anti-CD3 epsilon monoclonal antibody to induce synchronous apoptosis in the thymus of AND T-cell receptor (TCR) transgenic RAG-2-/- mice in a non-selecting haploty...

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Detalhes bibliográficos
Main Authors: Lerner, A, Clayton, L K, Mizoguchi, E, Ghendler, Y, van Ewijk, W, Koyasu, S, Bhan, A K, Reinherz, E L
Formato: Artigo
Idioma:Inglês
Publicado em: 1996
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC452343/
https://ncbi.nlm.nih.gov/pubmed/8918465
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