T-cell receptor ligation by peptide/MHC induces activation of a caspase in immature thymocytes: the molecular basis of negative selection.

T-cell receptors (TCRs) are created by a stochastic gene rearrangement process during thymocyte development, generating thymocytes bearing useful, as well as unwanted, specificities. Within the latter group, autoreactive thymocytes arise which are subsequently eliminated via a thymocyte-specific apo...

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Bibliographic Details
Main Authors: Clayton, L K, Ghendler, Y, Mizoguchi, E, Patch, R J, Ocain, T D, Orth, K, Bhan, A K, Dixit, V M, Reinherz, E L
Format: Artigo
Language:Inglês
Published: 1997
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1169830/
https://ncbi.nlm.nih.gov/pubmed/9171343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/16.9.2282
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