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Regulation of T cell receptor expression in immature CD4+CD8+ thymocytes by p56lck tyrosine kinase: basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules

Signals transduced through the T cell antigen receptor (TCR) are modulated by the src family tyrosine kinase p56lck (lck), which associates in mature T cells with the coreceptor molecules CD4 and CD8. Here we describe a novel function of lck in immature CD4+CD8+ thymocytes, that of regulating TCR ex...

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Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 1993
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2191226/
https://ncbi.nlm.nih.gov/pubmed/8228817
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