Regulation of T cell receptor expression in immature CD4+CD8+ thymocytes by p56lck tyrosine kinase: basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules

Lignende værker

• ZAP-70 Protein Promotes Tyrosine Phosphorylation of T Cell Receptor Signaling Motifs (ITAMs) in Immature CD4(+)8(+) Thymocytes with Limiting p56(lck)
  af: Ashe, Jennifer M., et al.
  Udgivet: (1999)
• Engagement of CD4 and CD8 expressed on immature thymocytes induces activation of intracellular tyrosine phosphorylation pathways
  Udgivet: (1989)
• Decreased signaling competence as a result of receptor overexpression: overexpression of CD4 reduces its ability to activate p56lck tyrosine kinase and to regulate T-cell antigen receptor expression in immature CD4+CD8+ thymocytes.
  af: Nakayama, T, et al.
  Udgivet: (1993)
• The coreceptor CD4 is expressed in distinct nanoclusters and does not colocalize with T-cell receptor and active protein tyrosine kinase p56lck
  af: Roh, Kyung-Ho, et al.
  Udgivet: (2015)
• CD8 Coreceptor Extinction in Signaled CD4(+)CD8(+) Thymocytes: Coordinate Roles for Both Transcriptional and Posttranscriptional Regulatory Mechanisms in Developing Thymocytes
  af: Cibotti, Ricardo, et al.
  Udgivet: (2000)