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Model-based prediction of the acute and long-term safety profile of naproxen in rats
BACKGROUND AND PURPOSE: Despite the increasing importance of biomarkers as predictors of drug effects, toxicology protocols continue to rely on the experimental evidence of adverse events (AEs) as a basis for establishing the link between indicators of safety and drug exposure. Furthermore, biomarke...
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| Опубликовано в: : | Br J Pharmacol |
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| Главные авторы: | , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
John Wiley & Sons, Ltd
2015
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4523341/ https://ncbi.nlm.nih.gov/pubmed/25884765 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13167 |
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