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Model-based prediction of the acute and long-term safety profile of naproxen in rats
BACKGROUND AND PURPOSE: Despite the increasing importance of biomarkers as predictors of drug effects, toxicology protocols continue to rely on the experimental evidence of adverse events (AEs) as a basis for establishing the link between indicators of safety and drug exposure. Furthermore, biomarke...
Gespeichert in:
| Veröffentlicht in: | Br J Pharmacol |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
John Wiley & Sons, Ltd
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4523341/ https://ncbi.nlm.nih.gov/pubmed/25884765 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13167 |
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