Model-based prediction of the acute and long-term safety profile of naproxen in rats

BACKGROUND AND PURPOSE: Despite the increasing importance of biomarkers as predictors of drug effects, toxicology protocols continue to rely on the experimental evidence of adverse events (AEs) as a basis for establishing the link between indicators of safety and drug exposure. Furthermore, biomarke...

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Bibliografiska uppgifter
I publikationen:Br J Pharmacol
Huvudupphovsmän: Sahota, Tarjinder, Sanderson, Ian, Danhof, Meindert, Della Pasqua, Oscar
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley & Sons, Ltd 2015
Ämnen:
Research Papers
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4523341/
https://ncbi.nlm.nih.gov/pubmed/25884765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13167
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