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The impact of composite AUC estimates on the prediction of systemic exposure in toxicology experiments
Current toxicity protocols relate measures of systemic exposure (i.e. AUC, C(max)) as obtained by non-compartmental analysis to observed toxicity. A complicating factor in this practice is the potential bias in the estimates defining safe drug exposure. Moreover, it prevents the assessment of variab...
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| Publicado en: | J Pharmacokinet Pharmacodyn |
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| Autores principales: | , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Springer US
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4432106/ https://ncbi.nlm.nih.gov/pubmed/25868863 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10928-015-9413-5 |
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