Depletion of Foxp3(+) T Cells Abrogates Tolerance of Skin and Heart Allografts in Murine Mixed Chimeras Without the Loss of Mixed Chimerism

The relative contribution of central and peripheral mechanisms to the generation and maintenance of allograft tolerance is of considerable interest. Here, we present new evidence that regulatory T cells (Foxp3(+)) maintain skin and heart allograft tolerance in mixed hematopoietic chimeric mice. Tran...

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Publicado en:Am J Transplant
Autores principales: Shinoda, K., Akiyoshi, T., Chase, C. M., Farkash, E. A., Ndishabandi, D. K., Raczek, C. M., Sebastian, D. P., Pelle, P. Della, Russell, P. S., Madsen, J. C., Colvin, R. B., Alessandrini, A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4523231/
https://ncbi.nlm.nih.gov/pubmed/25155089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/ajt.12851
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