Depletion of Foxp3(+) T Cells Abrogates Tolerance of Skin and Heart Allografts in Murine Mixed Chimeras Without the Loss of Mixed Chimerism

The relative contribution of central and peripheral mechanisms to the generation and maintenance of allograft tolerance is of considerable interest. Here, we present new evidence that regulatory T cells (Foxp3(+)) maintain skin and heart allograft tolerance in mixed hematopoietic chimeric mice. Tran...

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Bibliographic Details
Published in:Am J Transplant
Main Authors: Shinoda, K., Akiyoshi, T., Chase, C. M., Farkash, E. A., Ndishabandi, D. K., Raczek, C. M., Sebastian, D. P., Pelle, P. Della, Russell, P. S., Madsen, J. C., Colvin, R. B., Alessandrini, A.
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4523231/
https://ncbi.nlm.nih.gov/pubmed/25155089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/ajt.12851
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