RAS Mutations Affect Pattern of Metastatic Spread and Increase Propensity for Brain Metastasis in Colorectal Cancer

BACKGROUND: RAS and PIK3CA mutations in metastatic colorectal cancer (mCRC) have been associated with worse survival. We sought to evaluate the impact of RAS and PIK3CA mutations on cumulative incidence of metastasis to potentially curable sites of liver and lung and other sites such as bone and bra...

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Detalhes bibliográficos
Publicado no:Cancer
Main Authors: Yaeger, Rona, Cowell, Elizabeth, Chou, Joanne F., Gewirtz, Alexandra N., Borsu, Laetitia, Vakiani, Efsevia, Solit, David B., Rosen, Neal, Capanu, Marinela, Ladanyi, Marc, Kemeny, Nancy
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4523078/
https://ncbi.nlm.nih.gov/pubmed/25491172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.29196
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