Self-priming determines high type I IFN production by plasmacytoid dendritic cells

Plasmacytoid dendritic cells (pDCs) are responsible for the robust and immediate production of type I IFNs during viral infection. pDCs employ TLR7 and TLR9 to detect RNA and CpG motifs present in microbial genomes. CpG-A was the first synthetic stimulus available that induced large amounts of IFN-α...

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Pubblicato in:Eur J Immunol
Autori principali: Kim, Sarah, Kaiser, Vera, Beier, Esther, Bechheim, Matthias, Guenthner-Biller, Margit, Ablasser, Andrea, Berger, Michael, Endres, Stefan, Hartmann, Gunther, Hornung, Veit
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4523003/
https://ncbi.nlm.nih.gov/pubmed/24338737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201343806
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