Tumour-derived prostaglandin E(2) and transforming growth factor-β synergize to inhibit plasmacytoid dendritic cell-derived interferon-α

In previous studies we reported that plasmacytoid dendritic cells (PDC) infiltrating head and neck cancer tissue are functionally impaired, but the molecular basis for the functional deficiency remained unclear. Here we demonstrate that tumour-derived prostaglandin E2 (PGE(2)) and transforming growt...

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Autores principales: Bekeredjian-Ding, Isabelle, Schäfer, Meike, Hartmann, Evelyn, Pries, Ralph, Parcina, Marijo, Schneider, Philip, Giese, Thomas, Endres, Stefan, Wollenberg, Barbara, Hartmann, Gunther
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Science Inc 2009
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2770691/
https://ncbi.nlm.nih.gov/pubmed/20067543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2567.2009.03134.x
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