The role of aberrant VHL/HIF pathway elements in predicting clinical outcome to pazopanib therapy in patients with metastatic clear-cell renal cell carcinoma

PURPOSE: Inactivation of von Hippel-Lindau (VHL) gene in clear-cell renal cell carcinoma (RCC) leads to increased levels of hypoxia-inducible factors (HIFs) and overexpression of HIF target genes, such as vascular endothelial growth factor (VEGF) and others. VEGF-targeted agents are standard in adva...

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Bibliografiska uppgifter
I publikationen:Clin Cancer Res
Huvudupphovsmän: Choueiri, Toni K., Fay, André P., Gagnon, Robert, Lin, Ying, Bahamon, Brittany, Brown, Victoria, Rosenberg, Jonathan E., Hutson, Thomas E., Baker-Neblett, Katherine L., Carpenter, Christopher, Liu, Yuan, Pandite, Lini, Signoretti, Sabina
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4522695/
https://ncbi.nlm.nih.gov/pubmed/23881929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-0491
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