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Preemptive Genotyping of CYP2C8 and CYP2C9 Allelic Variants Involved in NSAIDs Metabolism for Sickle Cell Disease Pain Management

Interindividual variability in analgesic effects of nonsteroidal anti‐inflammatory drugs prescribed for sickle cell disease (SCD) pain is attributed to polymorphisms in the CYP2C8 and CYP2C9 enzymes. We described CYP2C8 and CYP2C9 genotype/phenotype profiles and frequency of emergency department (ED...

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Veröffentlicht in:Clin Transl Sci
Hauptverfasser: Jaja, Cheedy, Bowman, Latanya, Wells, Leigh, Patel, Niren, Xu, Hongyan, Lyon, Matt, Kutlar, Abdullah
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4522406/
https://ncbi.nlm.nih.gov/pubmed/25640739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cts.12260
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