Dermal delivery of HSP47 siRNA with NOX4-modulating mesoporous silica-based nanoparticles for treating fibrosis

Fibrotic diseases such as scleroderma have been linked to increased oxidative stress and upregulation of pro-fibrotic genes. Recent work suggests a role of NADPH oxidase 4 (NOX4) and heat shock protein 47 (HSP47) in inducing excessive collagen synthesis, leading to fibrotic diseases. Herein, we eluc...

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Pubblicato in:Biomaterials
Autori principali: Morry, Jingga, Ngamcherdtrakul, Worapol, Gu, Shenda, Goodyear, Shaun M., Castro, David J., Reda, Moataz M., Sangvanich, Thanapon, Yantasee, Wassana
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4522385/
https://ncbi.nlm.nih.gov/pubmed/26196532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2015.07.005
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