Loss of heterozygosity: what is it good for?

BACKGROUND: Loss of heterozygosity (LOH) is a common genetic event in cancer development, and is known to be involved in the somatic loss of wild-type alleles in many inherited cancer syndromes. The wider involvement of LOH in cancer is assumed to relate to unmasking a somatically mutated tumour sup...

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Detalles Bibliográficos
Publicado en:BMC Med Genomics
Autores principales: Ryland, Georgina L., Doyle, Maria A., Goode, David, Boyle, Samantha E., Choong, David Y.H., Rowley, Simone M., Li, Jason, Bowtell, David DL, Tothill, Richard W., Campbell, Ian G., Gorringe, Kylie L.
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4522148/
https://ncbi.nlm.nih.gov/pubmed/26231170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12920-015-0123-z
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