Loss of heterozygosity: what is it good for?

BACKGROUND: Loss of heterozygosity (LOH) is a common genetic event in cancer development, and is known to be involved in the somatic loss of wild-type alleles in many inherited cancer syndromes. The wider involvement of LOH in cancer is assumed to relate to unmasking a somatically mutated tumour sup...

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Detalhes bibliográficos
Publicado no:BMC Med Genomics
Main Authors: Ryland, Georgina L., Doyle, Maria A., Goode, David, Boyle, Samantha E., Choong, David Y.H., Rowley, Simone M., Li, Jason, Bowtell, David DL, Tothill, Richard W., Campbell, Ian G., Gorringe, Kylie L.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4522148/
https://ncbi.nlm.nih.gov/pubmed/26231170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12920-015-0123-z
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