Discovery of Novel Inhibitors and Fluorescent Probe Targeting NAMPT

Nicotinamide phosphoribosyltransferase (NAMPT) is a promising antitumor target. Novel NAMPT inhibitors with diverse chemotypes are highly desirable for development of antitumor agents. Using high throughput screening system targeting NAMPT on a chemical library of 30000 small-molecules, we found a n...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Wang, Xia, Xu, Tian-Ying, Liu, Xin-Zhu, Zhang, Sai-Long, Wang, Pei, Li, Zhi-Yong, Guan, Yun-Feng, Wang, Shu-Na, Dong, Guo-Qiang, Zhuo, Shu, Le, Ying-Ying, Sheng, Chun-Quan, Miao, Chao-Yu
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4521150/
https://ncbi.nlm.nih.gov/pubmed/26227784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep12657
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