Crystal structure-based comparison of two NAMPT inhibitors

Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) is a novel strategy for cancer therapy, but only two inhibitors of NAMPT (FK866 and CHS828) have progressed into clinical trials. This study seeks to compare a novel potent NAMPT inhibitor, MS0, with a classical inhibitor FK866 in their bi...

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Vydáno v:Acta Pharmacol Sin
Hlavní autoři: Zhang, Sai-long, Xu, Tian-ying, Yang, Zhen-Lin, Han, Shuo, Zhao, Qiang, Miao, Chao-yu
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2018
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5800471/
https://ncbi.nlm.nih.gov/pubmed/28858298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2017.80
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