Inhibition of Osteocyte Apoptosis Prevents the Increase in Osteocytic Receptor Activator of Nuclear Factor κB Ligand (RANKL) but Does Not Stop Bone Resorption or the Loss of Bone Induced by Unloading

Apoptosis of osteocytes and osteoblasts precedes bone resorption and bone loss with reduced mechanical stimulation, and receptor activator of NF-κB ligand (RANKL) expression is increased with unloading in mice. Because osteocytes are major RANKL producers, we hypothesized that apoptotic osteocytes s...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Biol Chem
Päätekijät: Plotkin, Lilian I., Gortazar, Arancha R., Davis, Hannah M., Condon, Keith W., Gabilondo, Hugo, Maycas, Marta, Allen, Matthew R., Bellido, Teresita
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2015
Aiheet:
Molecular Bases of Disease
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4521013/
https://ncbi.nlm.nih.gov/pubmed/26085098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.642090
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia