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Inhibition of Osteocyte Apoptosis Prevents the Increase in Osteocytic Receptor Activator of Nuclear Factor κB Ligand (RANKL) but Does Not Stop Bone Resorption or the Loss of Bone Induced by Unloading

Apoptosis of osteocytes and osteoblasts precedes bone resorption and bone loss with reduced mechanical stimulation, and receptor activator of NF-κB ligand (RANKL) expression is increased with unloading in mice. Because osteocytes are major RANKL producers, we hypothesized that apoptotic osteocytes s...

詳細記述

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書誌詳細
出版年:J Biol Chem
主要な著者: Plotkin, Lilian I., Gortazar, Arancha R., Davis, Hannah M., Condon, Keith W., Gabilondo, Hugo, Maycas, Marta, Allen, Matthew R., Bellido, Teresita
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4521013/
https://ncbi.nlm.nih.gov/pubmed/26085098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.642090
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