Inhibition of Osteocyte Apoptosis Prevents the Increase in Osteocytic Receptor Activator of Nuclear Factor κB Ligand (RANKL) but Does Not Stop Bone Resorption or the Loss of Bone Induced by Unloading

Apoptosis of osteocytes and osteoblasts precedes bone resorption and bone loss with reduced mechanical stimulation, and receptor activator of NF-κB ligand (RANKL) expression is increased with unloading in mice. Because osteocytes are major RANKL producers, we hypothesized that apoptotic osteocytes s...

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Bibliografski detalji
Izdano u:J Biol Chem
Glavni autori: Plotkin, Lilian I., Gortazar, Arancha R., Davis, Hannah M., Condon, Keith W., Gabilondo, Hugo, Maycas, Marta, Allen, Matthew R., Bellido, Teresita
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2015
Teme:
Molecular Bases of Disease
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4521013/
https://ncbi.nlm.nih.gov/pubmed/26085098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.642090
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