Parathyroid Hormone Receptor Signaling Induces Bone Resorption in the Adult Skeleton by Directly Regulating the RANKL Gene in Osteocytes

PTH upregulates the expression of the receptor activator of nuclear factor κB ligand (Rankl) in cells of the osteoblastic lineage, but the precise differentiation stage of the PTH target cell responsible for RANKL-mediated stimulation of bone resorption remains undefined. We report that constitutive...

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Detalhes bibliográficos
Main Authors: Ben-awadh, Abdullah N., Delgado-Calle, Jesus, Tu, Xiaolin, Kuhlenschmidt, Kali, Allen, Matthew R., Plotkin, Lilian I., Bellido, Teresita
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2014
Assuntos:
Calcium-Regulating Hormones
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4098003/
https://ncbi.nlm.nih.gov/pubmed/24877630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2014-1046
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