MMP14 is a novel target of PTH signaling in osteocytes that controls resorption by regulating soluble RANKL production

Parathyroid hormone (PTH) affects the skeleton by acting on osteocytes (Ots) in bone through yet unclear mechanisms. We report that matrix metalloproteinase 14 (MMP14) expression/activity are increased in bones from mice with genetic constitutive activation (ca) of the PTH receptor 1 (PTH1R) in Ots...

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Dettagli Bibliografici
Pubblicato in:FASEB J
Autori principali: Delgado-Calle, Jesus, Hancock, Benjamin, Likine, Elive F., Sato, Amy Y., McAndrews, Kevin, Sanudo, Carolina, Bruzzaniti, Angela, Riancho, Jose A., Tonra, James R., Bellido, Teresita
Natura: Artigo
Lingua:Inglês
Pubblicazione: Federation of American Societies for Experimental Biology 2018
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5901377/
https://ncbi.nlm.nih.gov/pubmed/29401593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201700919RRR
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