MMP14 is a novel target of PTH signaling in osteocytes that controls resorption by regulating soluble RANKL production

Parathyroid hormone (PTH) affects the skeleton by acting on osteocytes (Ots) in bone through yet unclear mechanisms. We report that matrix metalloproteinase 14 (MMP14) expression/activity are increased in bones from mice with genetic constitutive activation (ca) of the PTH receptor 1 (PTH1R) in Ots...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Delgado-Calle, Jesus, Hancock, Benjamin, Likine, Elive F., Sato, Amy Y., McAndrews, Kevin, Sanudo, Carolina, Bruzzaniti, Angela, Riancho, Jose A., Tonra, James R., Bellido, Teresita
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5901377/
https://ncbi.nlm.nih.gov/pubmed/29401593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201700919RRR
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