Inhibition of Osteocyte Apoptosis Prevents the Increase in Osteocytic Receptor Activator of Nuclear Factor κB Ligand (RANKL) but Does Not Stop Bone Resorption or the Loss of Bone Induced by Unloading

Apoptosis of osteocytes and osteoblasts precedes bone resorption and bone loss with reduced mechanical stimulation, and receptor activator of NF-κB ligand (RANKL) expression is increased with unloading in mice. Because osteocytes are major RANKL producers, we hypothesized that apoptotic osteocytes s...

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Publicat a:J Biol Chem
Autors principals: Plotkin, Lilian I., Gortazar, Arancha R., Davis, Hannah M., Condon, Keith W., Gabilondo, Hugo, Maycas, Marta, Allen, Matthew R., Bellido, Teresita
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2015
Matèries:
Molecular Bases of Disease
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4521013/
https://ncbi.nlm.nih.gov/pubmed/26085098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.642090
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