Therapeutic inhibition of TRF1 impairs the growth of p53-deficient K-Ras(G12V)-induced lung cancer by induction of telomeric DNA damage

Telomeres are considered anti-cancer targets, as telomere maintenance above a minimum length is necessary for cancer growth. Telomerase abrogation in cancer-prone mouse models, however, only decreased tumor growth after several mouse generations when telomeres reach a critically short length, and th...

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Bibliographic Details
Published in:EMBO Mol Med
Main Authors: García-Beccaria, María, Martínez, Paula, Méndez-Pertuz, Marinela, Martínez, Sonia, Blanco-Aparicio, Carmen, Cañamero, Marta, Mulero, Francisca, Ambrogio, Chiara, Flores, Juana M, Megias, Diego, Barbacid, Mariano, Pastor, Joaquín, Blasco, Maria A
Format: Artigo
Language:Inglês
Published: John Wiley & Sons, Ltd 2015
Subjects:
Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4520658/
https://ncbi.nlm.nih.gov/pubmed/25971796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201404497
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