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Therapeutic inhibition of TRF1 impairs the growth of p53-deficient K-Ras(G12V)-induced lung cancer by induction of telomeric DNA damage
Telomeres are considered anti-cancer targets, as telomere maintenance above a minimum length is necessary for cancer growth. Telomerase abrogation in cancer-prone mouse models, however, only decreased tumor growth after several mouse generations when telomeres reach a critically short length, and th...
Tallennettuna:
Julkaisussa: | EMBO Mol Med |
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Päätekijät: | , , , , , , , , , , , , |
Aineistotyyppi: | Artigo |
Kieli: | Inglês |
Julkaistu: |
John Wiley & Sons, Ltd
2015
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Aiheet: | |
Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4520658/ https://ncbi.nlm.nih.gov/pubmed/25971796 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201404497 |
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