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Bacillus anthracis Capsular Conjugates Elicit Chimpanzee Polyclonal Antibodies That Protect Mice from Pulmonary Anthrax

The immunogenicity of Bacillus anthracis capsule (poly-γ-d-glutamic acid [PGA]) conjugated to recombinant B. anthracis protective antigen (rPA) or to tetanus toxoid (TT) was evaluated in two anthrax-naive juvenile chimpanzees. In a previous study of these conjugates, highly protective monoclonal ant...

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Détails bibliographiques
Publié dans:Clin Vaccine Immunol
Auteurs principaux: Chen, Zhaochun, Schneerson, Rachel, Lovchik, Julie A., Dai, Zhongdong, Kubler-Kielb, Joanna, Agulto, Liane, Leppla, Stephen H., Purcell, Robert H.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4519721/
https://ncbi.nlm.nih.gov/pubmed/26041039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00137-15
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