Pre- and postexposure protection against virulent anthrax infection in mice by humanized monoclonal antibodies to Bacillus anthracis capsule

One of the two essential virulence factors of Bacillus anthracis is the poly-γ-d-glutamic acid (γDPGA) capsule. Five γDPGA-specific antibody antigen-binding fragments (Fabs) were generated from immunized chimpanzees. The two selected for further study, Fabs 11D and 4C, were both converted into full-...

Full description

Saved in:
Bibliographic Details
Main Authors: Chen, Zhaochun, Schneerson, Rachel, Lovchik, Julie, Lyons, C. Rick, Zhao, Huaying, Dai, Zhongdong, Kubler-Kielb, Joanna, Leppla, Stephen H., Purcell, Robert H.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2011
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3021070/
https://ncbi.nlm.nih.gov/pubmed/21187383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1017677108
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items