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Voltage-gated sodium channels and cancer: is excitability their primary role?

Voltage-gated sodium channels (Na(V)) are molecular characteristics of excitable cells. Their activation, triggered by membrane depolarization, generates transient sodium currents that initiate action potentials in neurons and muscle cells. Sodium currents were discovered by Hodgkin and Huxley using...

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Опубликовано в: :Front Pharmacol
Главные авторы: Roger, Sébastien, Gillet, Ludovic, Le Guennec, Jean-Yves, Besson, Pierre
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Media S.A. 2015
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4518325/
https://ncbi.nlm.nih.gov/pubmed/26283962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2015.00152
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