Curcumin-Mediated HDAC Inhibition Suppresses the DNA Damage Response and Contributes to Increased DNA Damage Sensitivity

Chemo- and radiotherapy cause multiple forms of DNA damage and lead to the death of cancer cells. Inhibitors of the DNA damage response are candidate drugs for use in combination therapies to increase the efficacy of such treatments. In this study, we show that curcumin, a plant polyphenol, sensitiz...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Wang, Shu-Huei, Lin, Pei-Ya, Chiu, Ya-Chen, Huang, Ju-Sui, Kuo, Yi-Tsen, Wu, Jen-Chine, Chen, Chin-Chuan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4517890/
https://ncbi.nlm.nih.gov/pubmed/26218133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0134110
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