Targeting HR Repair as a Synthetic Lethal Approach to Increase DNA Damage Sensitivity by a RAD52 Inhibitor in BRCA2-Deficient Cancer Cells

BRCA mutation, one of the most common types of mutations in breast and ovarian cancer, has been suggested to be synthetically lethal with depletion of RAD52. Pharmacologically inhibiting RAD52 specifically eradicates BRCA-deficient cancer cells. In this study, we demonstrated that curcumin, a plant...

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Publicado en:Int J Mol Sci
Main Authors: Tseng, Wei-Che, Chen, Chi-Yuan, Chern, Ching-Yuh, Wang, Chu-An, Lee, Wen-Chih, Chi, Ying-Chih, Cheng, Shu-Fang, Kuo, Yi-Tsen, Chiu, Ya-Chen, Tseng, Shih-Ting, Lin, Pei-Ya, Liou, Shou-Jhen, Li, Yi-Chen, Chen, Chin-Chuan
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2021
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8122931/
https://ncbi.nlm.nih.gov/pubmed/33922657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22094422
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