Targeting HR Repair as a Synthetic Lethal Approach to Increase DNA Damage Sensitivity by a RAD52 Inhibitor in BRCA2-Deficient Cancer Cells

BRCA mutation, one of the most common types of mutations in breast and ovarian cancer, has been suggested to be synthetically lethal with depletion of RAD52. Pharmacologically inhibiting RAD52 specifically eradicates BRCA-deficient cancer cells. In this study, we demonstrated that curcumin, a plant...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Int J Mol Sci
Κύριοι συγγραφείς: Tseng, Wei-Che, Chen, Chi-Yuan, Chern, Ching-Yuh, Wang, Chu-An, Lee, Wen-Chih, Chi, Ying-Chih, Cheng, Shu-Fang, Kuo, Yi-Tsen, Chiu, Ya-Chen, Tseng, Shih-Ting, Lin, Pei-Ya, Liou, Shou-Jhen, Li, Yi-Chen, Chen, Chin-Chuan
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: MDPI 2021
Θέματα:
Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8122931/
https://ncbi.nlm.nih.gov/pubmed/33922657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22094422
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