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Structural design of disialoganglioside GD2 and CD3-bispecific antibodies to redirect T cells for tumor therapy
Antibody based immunotherapy has proven efficacy for patients with high risk neuroblastoma. However, despite being the most efficient tumoricidal effectors, T cells are underutilized because they lack Fc receptors. Using a monovalent single chain fragment (ScFv) platform, we engineered tandem scFv b...
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| Publié dans: | Int J Cancer |
|---|---|
| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2014
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4517675/ https://ncbi.nlm.nih.gov/pubmed/24895182 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.29007 |
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