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Anti-CD3 × Anti-GD2 Bispecific Antibody Redirects T-Cell Cytolytic Activity to Neuroblastoma Targets

BACKGROUND: The ganglioside GD2 is an attractive target for immunotherapy of neuroectodermal tumors. We tested a unique bispecific antibody anti-CD3 × anti-GD2 (3F8BiAb) for its ability to redirect activated T cells (ATC) to target GD2-positive neuroblastomas. PROCEDURE: ATC were generated from norm...

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Detalhes bibliográficos
Main Authors: Yankelevich, Maxim, Kondadasula, Sri Vidya, Thakur, Archana, Buck, Steven, Cheung, Nai-Kong V., Lum, Lawrence G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3792711/
https://ncbi.nlm.nih.gov/pubmed/22707078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.24237
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