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Functionalized PHB granules provide the basis for the efficient side-chain cleavage of cholesterol and analogs in recombinant Bacillus megaterium

BACKGROUND: Cholesterol, the precursor of all steroid hormones, is the most abundant steroid in vertebrates and exhibits highly hydrophobic properties, rendering it a difficult substrate for aqueous microbial biotransformations. In the present study, we developed a Bacillus megaterium based whole-ce...

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Pubblicato in:Microb Cell Fact
Autori principali: Gerber, Adrian, Kleser, Michael, Biedendieck, Rebekka, Bernhardt, Rita, Hannemann, Frank
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4517628/
https://ncbi.nlm.nih.gov/pubmed/26215140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12934-015-0300-y
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