P-glycoprotein confers acquired resistance to 17-DMAG in lung cancers with an ALK rearrangement

BACKGROUND: Because anaplastic lymphoma kinase (ALK) is dependent on Hsp90 for protein stability, Hsp90 inhibitors are effective in controlling growth of lung cancer cells with ALK rearrangement. We investigated the mechanism of acquired resistance to 17-(Dimethylaminoethylamino)-17-demethoxygeldana...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:BMC Cancer
Hauptverfasser: Kim, Hee Joung, Lee, Kye Young, Kim, Young Whan, Choi, Yun Jung, Lee, Jung-Eun, Choi, Chang Min, Baek, In-Jeoung, Rho, Jin Kyung, Lee, Jae Cheol
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4517346/
https://ncbi.nlm.nih.gov/pubmed/26219569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1543-z
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge