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P-glycoprotein confers acquired resistance to 17-DMAG in lung cancers with an ALK rearrangement
BACKGROUND: Because anaplastic lymphoma kinase (ALK) is dependent on Hsp90 for protein stability, Hsp90 inhibitors are effective in controlling growth of lung cancer cells with ALK rearrangement. We investigated the mechanism of acquired resistance to 17-(Dimethylaminoethylamino)-17-demethoxygeldana...
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| Wydane w: | BMC Cancer |
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| Główni autorzy: | , , , , , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
BioMed Central
2015
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4517346/ https://ncbi.nlm.nih.gov/pubmed/26219569 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1543-z |
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