P-glycoprotein confers acquired resistance to 17-DMAG in lung cancers with an ALK rearrangement

BACKGROUND: Because anaplastic lymphoma kinase (ALK) is dependent on Hsp90 for protein stability, Hsp90 inhibitors are effective in controlling growth of lung cancer cells with ALK rearrangement. We investigated the mechanism of acquired resistance to 17-(Dimethylaminoethylamino)-17-demethoxygeldana...

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Vydáno v:BMC Cancer
Hlavní autoři: Kim, Hee Joung, Lee, Kye Young, Kim, Young Whan, Choi, Yun Jung, Lee, Jung-Eun, Choi, Chang Min, Baek, In-Jeoung, Rho, Jin Kyung, Lee, Jae Cheol
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2015
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4517346/
https://ncbi.nlm.nih.gov/pubmed/26219569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1543-z
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