P-glycoprotein confers acquired resistance to 17-DMAG in lung cancers with an ALK rearrangement

BACKGROUND: Because anaplastic lymphoma kinase (ALK) is dependent on Hsp90 for protein stability, Hsp90 inhibitors are effective in controlling growth of lung cancer cells with ALK rearrangement. We investigated the mechanism of acquired resistance to 17-(Dimethylaminoethylamino)-17-demethoxygeldana...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Kim, Hee Joung, Lee, Kye Young, Kim, Young Whan, Choi, Yun Jung, Lee, Jung-Eun, Choi, Chang Min, Baek, In-Jeoung, Rho, Jin Kyung, Lee, Jae Cheol
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4517346/
https://ncbi.nlm.nih.gov/pubmed/26219569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1543-z
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