A lipid switch unlocks Parkinson’s disease-associated ATP13A2

ATP13A2 is a lysosomal P-type transport ATPase that has been implicated in Kufor–Rakeb syndrome and Parkinson’s disease (PD), providing protection against α-synuclein, Mn(2+), and Zn(2+) toxicity in various model systems. So far, the molecular function and regulation of ATP13A2 remains undetermined....

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發表在:Proc Natl Acad Sci U S A
Main Authors: Holemans, Tine, Sørensen, Danny Mollerup, van Veen, Sarah, Martin, Shaun, Hermans, Diane, Kemmer, Gerdi Christine, Van den Haute, Chris, Baekelandt, Veerle, Günther Pomorski, Thomas, Agostinis, Patrizia, Wuytack, Frank, Palmgren, Michael, Eggermont, Jan, Vangheluwe, Peter
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2015
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4517210/
https://ncbi.nlm.nih.gov/pubmed/26134396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1508220112
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