Protection against Mitochondrial and Metal Toxicity Depends on Functional Lipid Binding Sites in ATP13A2

The late endo-/lysosomal P-type ATPase ATP13A2 (PARK9) is implicated in Parkinson's disease (PD) and Kufor-Rakeb syndrome, early-onset atypical Parkinsonism. ATP13A2 interacts at the N-terminus with the signaling lipids phosphatidic acid (PA) and phosphatidylinositol (3,5) bisphosphate (PI(3,5)...

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Bibliographic Details
Published in:Parkinsons Dis
Main Authors: Martin, Shaun, van Veen, Sarah, Holemans, Tine, Demirsoy, Seyma, van den Haute, Chris, Baekelandt, Veerle, Agostinis, Patrizia, Eggermont, Jan, Vangheluwe, Peter
Format: Artigo
Language:Inglês
Published: Hindawi Publishing Corporation 2016
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4814700/
https://ncbi.nlm.nih.gov/pubmed/27073711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/9531917
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