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Blocking neutrophil integrin activation prevents ischemia–reperfusion injury
Neutrophil recruitment, mediated by β2 integrins, combats pyogenic infections but also plays a key role in ischemia–reperfusion injury and other inflammatory disorders. Talin induces allosteric rearrangements in integrins that increase affinity for ligands (activation). Talin also links integrins to...
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| Pubblicato in: | J Exp Med |
|---|---|
| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The Rockefeller University Press
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4516797/ https://ncbi.nlm.nih.gov/pubmed/26169939 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20142358 |
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