PDGFRA Regulates Proliferation of Gastrointestinal Stromal Tumor Cells with Mutations in KIT by Stabilizing ETV1

BACKGROUND & AIMS: In gastrointestinal muscles, KIT is predominantly expressed by interstitial cells of Cajal (ICC) and PDGFRA is expressed by so-called fibroblast-like cells. KIT and PDGFRA have been reported to be co-expressed in ICC precursors and gastrointestinal stromal tumors (GISTs), whic...

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Publicat a:Gastroenterology
Autors principals: Hayashi, Yujiro, Bardsley, Michael R., Toyomasu, Yoshitaka, Milosavljevic, Srdjan, Gajdos, Gabriella B., Choi, Kyoung Moo, Reid-Lombardo, KMarie, Kendrick, Michael L., Bingener-Casey, Juliane, Tang, Chih-Min, Sicklick, Jason K., Gibbons, Simon J., Farrugia, Gianrico, Taguchi, Takahiro, Gupta, Anu, Rubin, Brian P., Fletcher, Jonathan A., Ramachandran, Abhijit, Ordog, Tamas
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4516576/
https://ncbi.nlm.nih.gov/pubmed/25865047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2015.04.006
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