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Did α-Synuclein and Glucocerebrosidase Coevolve? Implications for Parkinson’s Disease

Mutations in the GBA1 gene are associated with increased risk of Parkinson's disease, and the protein produced by the gene, glucocerebrosidase, interacts with α-synuclein, the protein at the center of the disease etiology. One possibility is that the mutations disrupt a beneficial interaction b...

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Bibliografski detalji
Izdano u:PLoS One
Glavni autor: Gruschus, James M.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4516260/
https://ncbi.nlm.nih.gov/pubmed/26214314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0133863
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