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Did α-Synuclein and Glucocerebrosidase Coevolve? Implications for Parkinson’s Disease

Mutations in the GBA1 gene are associated with increased risk of Parkinson's disease, and the protein produced by the gene, glucocerebrosidase, interacts with α-synuclein, the protein at the center of the disease etiology. One possibility is that the mutations disrupt a beneficial interaction b...

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Vydáno v:PLoS One
Hlavní autor: Gruschus, James M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4516260/
https://ncbi.nlm.nih.gov/pubmed/26214314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0133863
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