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Did α-Synuclein and Glucocerebrosidase Coevolve? Implications for Parkinson’s Disease
Mutations in the GBA1 gene are associated with increased risk of Parkinson's disease, and the protein produced by the gene, glucocerebrosidase, interacts with α-synuclein, the protein at the center of the disease etiology. One possibility is that the mutations disrupt a beneficial interaction b...
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| Publicado no: | PLoS One |
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| Autor principal: | |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4516260/ https://ncbi.nlm.nih.gov/pubmed/26214314 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0133863 |
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