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Did α-Synuclein and Glucocerebrosidase Coevolve? Implications for Parkinson’s Disease
Mutations in the GBA1 gene are associated with increased risk of Parkinson's disease, and the protein produced by the gene, glucocerebrosidase, interacts with α-synuclein, the protein at the center of the disease etiology. One possibility is that the mutations disrupt a beneficial interaction b...
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| Veröffentlicht in: | PLoS One |
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| 1. Verfasser: | |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4516260/ https://ncbi.nlm.nih.gov/pubmed/26214314 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0133863 |
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