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Urokinase receptor and resistance to targeted anticancer agents

The urokinase receptor (uPAR) is a GPI-anchored membrane protein, which regulates protease activity at the cell surface and, in collaboration with a system of co-receptors, triggers cell-signaling and regulates gene expression within the cell. In normal tissues, uPAR gene expression is limited; howe...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Gonias, Steven L., Hu, Jingjing
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4515545/
https://ncbi.nlm.nih.gov/pubmed/26283964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2015.00154
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