Abnormal synaptic Ca(2+) homeostasis and morphology in cortical neurons of familial hemiplegic migraine type 1 mutant mice

OBJECTIVE: Migraine is one of the most common and debilitating neurological conditions. Familial hemiplegic migraine type 1 (FHM1), a monogenic migraine subtype, is caused by gain-of-function of voltage-gated Ca(V)2.1 calcium channels. FHM1 mice carry human pathogenic mutations in the α(1A) subunit...

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Publicado no:Ann Neurol
Main Authors: Eikermann-Haerter, Katharina, Arbel-Ornath, Michal, Yalcin, Nilufer, Yu, Esther S., Kuchibhotla, Kishore V., Yuzawa, Izumi, Hudry, Eloise, Lattarulo, Carli R., Climov, Mihail, Keles, Fatmagul, Belcher, Arianna M., Sengul, Buse, Negro, Andrea, Rosen, Isaac A., Arreguin, Andrea, Ferrari, Michel D., van den Maagdenberg, Arn M. J. M., Bacskai, Brian J., Ayata, Cenk
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4515184/
https://ncbi.nlm.nih.gov/pubmed/26032020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.24449
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