Enhanced Subcortical Spreading Depression in Familial Hemiplegic Migraine Type 1 Mutant Mice

Familial hemiplegic migraine type 1, a monogenic migraine variant with aura, is linked to gain-of-function mutations in the CACNA1A gene encoding Ca(V)2.1 channels. The S218L mutation causes severe channel dysfunction, and paroxysmal migraine attacks can be accompanied by seizures, coma, and hemiple...

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Hlavní autoři: Eikermann-Haerter, Katharina, Yuzawa, Izumi, Qin, Tao, Wang, Yumei, Baek, Kwangyeol, Kim, Young Ro, Hoffmann, Ulrike, Dilekoz, Ergin, Waeber, Christian, Ferrari, Michel D., van den Maagdenberg, Arn M. J. M., Moskowitz, Michael A., Ayata, Cenk
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3135337/
https://ncbi.nlm.nih.gov/pubmed/21490217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5346-10.2011
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