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The pattern of congenital heart defects arising from reduced Tbx5 expression is altered in a Down syndrome mouse model
BACKGROUND: Nearly half of all individuals with Down Syndrome (DS) have some type of congenital heart defect (CHD), suggesting that DS sensitizes to CHD but does not cause it. We used a common mouse model of DS, the Ts65Dn mouse, to study the contribution of Tbx5, a known modifier of CHD, to heart d...
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| Publicado no: | BMC Dev Biol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4514943/ https://ncbi.nlm.nih.gov/pubmed/26208718 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12861-015-0080-y |
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