The pattern of congenital heart defects arising from reduced Tbx5 expression is altered in a Down syndrome mouse model

BACKGROUND: Nearly half of all individuals with Down Syndrome (DS) have some type of congenital heart defect (CHD), suggesting that DS sensitizes to CHD but does not cause it. We used a common mouse model of DS, the Ts65Dn mouse, to study the contribution of Tbx5, a known modifier of CHD, to heart d...

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Detalles Bibliográficos
Publicado en:BMC Dev Biol
Main Authors: Polk, Renita C., Gergics, Peter, Steimle, Jeffrey D., Li, Huiqing, Moskowitz, Ivan P., Camper, Sally A., Reeves, Roger H.
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2015
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4514943/
https://ncbi.nlm.nih.gov/pubmed/26208718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12861-015-0080-y
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