SPARSE: quadratic time simultaneous alignment and folding of RNAs without sequence-based heuristics

Motivation: RNA-Seq experiments have revealed a multitude of novel ncRNAs. The gold standard for their analysis based on simultaneous alignment and folding suffers from extreme time complexity of [Formula: see text]. Subsequently, numerous faster ‘Sankoff-style’ approaches have been suggested. Commo...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Bioinformatics
Main Authors: Will, Sebastian, Otto, Christina, Miladi, Milad, Möhl, Mathias, Backofen, Rolf
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2015
Teme:
Original Papers
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4514930/
https://ncbi.nlm.nih.gov/pubmed/25838465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btv185
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